A gentler way to feel more like yourself again, through the natural changes that come after 40.
VS-09®: The Hormone Formula was created for women navigating the shifts that often come in their forties, when cortisol, blood sugar, and cravings no longer behave quite the way they used to. Nine clinical actives, in two small capsules a day. No HRT, no injections, just calm everyday support.
- Cortisol balance support (Ashwagandha)*
- 1,000 mg Berberine, a well-studied dose
- Helps ease everyday sugar & carb cravings
- Grounded in 340+ published studies
*Ashwagandha root extract is studied in published clinical trials for its effect on cortisol. Individual results vary.
These are all symptoms of cortisol stuck “on” and estrogen sliding “off.”
The combination forces the body to hold onto FAT and WATER at the same time. And that’s only what you see in the mirror.
Cortisol stuck “on”, estrogen sliding “off”: how the body is reshaped, and how it returns.
Inside, a slow-motion hormonal collapse is rewriting how your body works.
You feel exhausted by 2pm and snappy by 5. Wired and tired when you need to sleep. Unable to drop a single pound, no matter how clean you eat.
If that’s been your last 18 months, it’s not your fault. These are textbook signs of cortisol stuck in alarm mode 24 hours a day.
And it doesn’t stop there.
By the time the average woman reaches menopause, her key reproductive hormones decline substantially.
When they leave, the body doesn’t gracefully adapt. The body panics.
Here’s why:
If you’ve noticed:
- A face in photos that looks softer than the one you remember
- A midsection no plank, no diet, no run can reach
- Jeans that fit Monday and not Friday
- Sleep that ends at 3:47am and refuses to come back
You’re not alone.
It’s happening to tens of millions of American women right now.
And if you’ve experienced any of these symptoms, you’ve probably also noticed something else.
Diet and exercise just won’t cut it anymore.
You can’t out-exercise cortisol. You can’t out-diet falling estrogen. You can’t out-discipline a hormonal switch.
But you can intervene at the switch.
There’s one way to support all three. And it doesn’t pass through the gym or the kitchen. It passes through the three hormones doing the damage.
in the Rhapontic Rhubarb trial
(Harvard-studied dose)
Do those three things, every day, for sixty days. And the body that has been fighting you starts cooperating again.
Built around the hormonal shifts so many women navigate through perimenopause.
A Single Daily Formula To Support Healthy Cortisol Balance, Support You Through Hot Flashes, And Support Healthy Glucose Metabolism. VS-09®: The Hormone Formula.
Vesper Science was founded by a woman who stopped sleeping at 47, and started reading the studies at 48.
Three years, 340 peer-reviewed trials, one obsession: identify the molecules that actually moved the needle on cortisol, estrogen receptors, and insulin sensitivity in published clinical research. Across Harvard Medical School, the Menopause journal, and the German pharmacopoeia archives.
Then she built one formula:
Nine clinically-dosed actives. Every dose matched to the dose the trial actually used. A peri-menopause formula built to address cortisol, estrogen, and insulin in a single daily protocol, at clinical strength. Not 30 ingredients at marketing doses. Nine ingredients, at pharmacological ones.
To support the body through stubborn weight, bloating, and low energy after 40: the three-hormone shift that diet and exercise alone don’t address.
All It Takes Is 2 Capsules A Day To Support Your Body Through Hormonal Weight, Puffiness, and Bloating...
While Supporting Deep Sleep, Steady Mood, And A Healthy Libido.
- Contains 9 standardized extracts, adaptogens, and nutrients hand-selected by Vesper’s nutrition and clinical research team.
- Backed by 340 peer-reviewed studies, Harvard Medical School research, and the Menopause journal, each selected for its published clinical backing.
- Measured at the dose used in published clinical research to support the body through the hormonal shifts of perimenopause. Pharmacological, not marketing.
- Helps support the body through puffiness and bloating while also supporting deep sleep and mood balance.
- Works without hormone replacement therapies, restrictive diets, or intense exercise.
The nine actives.
Each one at the dose the published clinical literature actually used.
Berberine HCL 97%
Pharmaceutical-grade dose. Studied at Harvard for glucose metabolism and insulin response.Harvard Medical School.
Ashwagandha root extract
Studied for its cortisol-lowering effects in published clinical trials. Cortisol influences where the body stores fat around the abdomen.3,000 years of traditional use.
Rhapontic Rhubarb (ERβ-selective)
ERβ-selective. In the ingredient’s 12-week clinical trial (109 women), participants reported 68% fewer hot flashes. Better sleep supports lower cortisol.Menopause Journal, 2006.
Magnesium Bisglycinate Chelate
Patented TRAACS form, superior absorption. Drives 300+ enzymes including water balance, insulin response, and fat conversion.
Black Cohosh
Remifemin protocol heritage, 40 years of European clinical evidence. Supports the 2am-4am deep-sleep window.
Saffron extract (Crocus sativus)
Most clinically studied saffron in the world. Supports mood and appetite balance via serotonin modulation.
Vitamin B6 (P5P)
Active coenzyme directly usable by the body. Cofactor for serotonin and dopamine synthesis.
Vitamin K2 MK-7
Trans-isomer >99%. Directs calcium to bones, away from arteries. Long-term bone and cardiovascular support.
BioPerine®
Patented absorption enhancer. Without it, up to 60% of the other eight actives pass unabsorbed.
The 6 Most Important Peri-Meno Research Advances Of The Past 30 Years...
Locked Into Two Daily Capsules.
These 6 brand new scientific discoveries are the most important advances in peri-menopausal support research in three decades...
Together, they address the three-hormone cascade that no diet, no treadmill, and no willpower can reach...
Without HRT, without injections, and without another lecture about eating less.
Advance
Harvard research on the alkaloid studied to support healthy glucose and insulin metabolism, even after 40
Harvard-studied alkaloid researched for glucose and insulin metabolism. The published research used a 1,000 mg daily dose over 12 weeks.
Advance
Indian Ayurvedic root studied for its effect on the stress hormone cortisol
Ashwagandha (5% withanolides) has been studied in double-blind clinical trials for its cortisol-lowering effects. Cortisol influences where the body stores fat around the abdomen.
Advance
Siberian root studied for its ERβ-selective activity and its effect on hot flashes and sleep quality
In a 12-week trial on this extract, published in the Menopause journal, 109 peri-menopausal women reported a 68% reduction in hot flashes. Better sleep supports lower cortisol and overall balance.
Advance
Persian spice studied for its effect on mood and appetite balance
The most clinically studied saffron in the world (3.5% safranal and crocins). It has been studied for supporting mood and appetite balance via serotonin and dopamine modulation.
Advance
Patented American chelated magnesium supports healthy water balance and the 300+ enzymes involved in metabolism
Magnesium drives 300+ enzymatic reactions: water balance, insulin response, and energy metabolism. Vesper uses TRAACS-grade chelated magnesium, the patented form with superior absorption.
Advance
40 years of European clinical research on the herb studied for night sweat and sleep support
The herb behind the Remifemin protocol, the European clinical standard for 40+ years. Studied for night sweat support without acting on breast or uterine tissue, supporting the deep-sleep window.
Aggregated across
peer-reviewed studies
on the 9 actives in VS-09®
What Women Reported
In the published clinical research on each of the 9 standardized actives in VS-09®, women reported measurable improvements in:
- Support for healthy body composition
- Cortisol support (studied in the Ashwagandha clinical trial)
- Fewer hot flashes and night sweats (68% reduction in the Rhapontic ingredient trial)
- Glucose metabolism support (Harvard, 1,000 mg Berberine dose)
- Mood and appetite balance support (Saffron extract)
- Deeper sleep cycles (Ashwagandha + Magnesium + Black Cohosh combined)
- Less water retention and puffiness (TRAACS chelated magnesium)
Not 30 ingredients at marketing doses. Nine ingredients, at pharmacological ones. The math is what does the work.
Made For Women Navigating Perimenopause:
Whatever Stubborn Weight, Bloating, And Water Retention Have Looked Like For You
-
Support A Slimmer-Feeling Midsection And Less Puffiness
Many women report feeling less puffy in the face and midsection within the first few weeks, as the body settles into a calmer cortisol rhythm.
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Sleep Like You Did At 32, Without Tossing And Turning
Cortisol settles overnight. Deep, restorative sleep becomes easier to reach, the overnight window when the body does much of its repair work.
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Rekindle Desire, Bring Back The Spark You Misplaced
Feel more like yourself again, before “too tired” and “too moody” became your default setting. As hormones find their balance, desire often follows.
-
Support Your Body’s Natural Balance, Without Restrictive Diets
No punishing workouts, calorie counting, or restrictive eating required. The body finds its balance more easily once hormones are supported.
-
Enjoy Your Favorite Meals Without The Usual Bloat
Say yes to dinner with friends, and to the foods you actually love, without the guilt, the bloat, or the cortisol spike that comes with restriction.
Built with discipline
Built clean. Tested clean. Dosed clinical.
Vegan & allergen-free
Caffeine-free, dye-free
FDA-registered & GMP-certified
340 peer-reviewed studies
Independent lab tested
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60-day, 100% money-back guarantee
At Vesper, if you don’t feel the protocol is right for you, we refund the bottle in full. We carry the risk, not you.
Free US shipping over $90
Buy 2 bottles or more, shipping is on us. Tracked, 5 to 8 business days, discreet packaging with no branding visible from outside.
60-day money-back
Many women report first noticing shifts in sleep, mood, and calm within the first few weeks, and individual results vary. You have 60 days to decide if VS-09 belongs in your routine. If not, full refund of the bottle.
No forms, no questions
No 12-page return form. No phone tree. Email us within 60 days, even with an empty bottle, and we process the refund within 48 hours. We refund you because we believe you.
What’s actually in VS-09®?
Nine Clinically-Dosed Actives. Every Single Dose Printed On The Label.
Still on the fence?
Twelve questions women ask before starting VS-09.
How is VS-09 different from a multivitamin?
Is this hormone replacement therapy (HRT)?
When will I notice a difference?
Can I take it with my current medications?
Is it safe long-term?
What if I'm already on HRT?
Is it third-party tested?
How many capsules per day?
What if it doesn't work for me?
Is it gluten-free / vegan / non-GMO?
Where is it made?
What's your return policy?
60-day money-back guarantee · No forms, no questions